P-70 Co-infection with Helicobacter pylori and Epstein-Barr virus occurs at early stage of gastric carcinogenesis

Simultaneous infection with Epstein-Barr virus (EBV) and Helicobacter pylori (H. pylori) can occur. Several researchers suggested that H. would accelerate to the occurrence development of EBV-positive gastric cancer (EBV-GC). However, possible interaction in carcinogenesis is still debatable. From January 2020 December 2021, a retrospective cohort study was performed 27 patients EBV-GCs. During same period, total 300 non EBV-GCs were control group. The detection EBV using mRNA situ hybridization, we compared clinicopathologic factors clinical outcomes between frequency 8.3% (27/327). rate early cancers (EGCs) 40.7% (11/27) EBV-GCs, whereas it 47.0% (141/300, p=0.29) non-EBV-GCs. rates 48.1% (13/ 27) 48.0% (144/ 300), respectively (p=0.91). In more frequent EGCa than advanced (8/ 11 vs. 5/ 16, p=0.03). state not different (73/ 141 71 /159, p=0.88). co-infection occurs at stage carcinogenesis.